5-dihydroxyphenylglycine; CA1 region; excitability; H89; HCN1 channel; LY367385; mGluR1; pentylenetetrazole; status epilepticus

Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel

Dysregulation of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels alters neuronal excitability. However, the role of HCN channels in status epilepticus is not fully understood. In this study, we established rat models of …